Vertical Spine is a commercial stage orthobiologics company with a unique, high yield, easy to use system providing intra-procedural collection and highly consistent preparation of two autologous Platelet-rich Fibrin Matrix (PRFM) Membrane Grafts and a Surgeon-Defined Graft in forms that facilitate targeted placement in the spine. As a licensee from the successful Cascade Medical Enterprises (CME), Vertical Spine has licensed patents from CME, where this technology has been commercialized for bone and soft tissue applications in markets including orthopedic sports medicine, wound care, cranial maxillofacial surgery, periodontics and veterinary medicine. Over 130,000 patients have been treated successfully in these procedure areas.

Vertical Spine’s 510(k) cleared FIBRINET® products are successfully being used in an IRB approved 80+ patient spinal study by the Hospital for Special Surgery in NYC. This study defined the surgical techniques and factors required for integration of FIBRINET® products into standard lumbar fusion procedures. This study established user-driven kit specifications to facilitate intra-operative ‘fit-in-practice’ use.

The FIBRINET® System allows the rapid concentration of autologous, intact platelets and fibrin, which produce a surgeon defined graft and two fibrin membrane grafts with sustained (7+ days) platelet viability. Viable platelets have been proven in literature to express growth factors in a sustained manner. Together with the fibrin matrix that is produced, the FIBRINET® System provides the cells, signals, and scaffold required for tissue repair and growth. 1, 2, 3

  1. Roy S, Sen CK, et al. Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation. Wound Rep Regen. 2011;19(6):753-766.
  2. Lucarelli E, et al. A recently developed bifacial platelet-rich fibrin matrix. Eur Cells Materials 2010;20:13-23.
  3. Visser LC, Arnoczky SP, Caballero O, et al. Platelet-rich fibrin constructs elute higher concentrations of TGF-β1 and increase tendon cell proliferation over time when compared to blood clots of similar volume: A comparative in vitro analysis. Vet Surg. 2010c; 39(7):811-817.


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